Deese Willie A

Deese Willie A

19 Jan 22

Deese Willie A

12 Jul 16

Deese Willie A

18 Nov 14

Deese Willie A

15 Oct 13

Deese Willie A

06 Feb 06

Eshelman Fredric N

Eshelman Ventures, Llc

13 Jan 21

Eshelman Ventures, Llc

01 Dec 20

Eshelman Fredric N

21 Jun 16

14 Feb 11

Eshelman Fredric N

17 Jul 07

Hanson James S.

Hanson James S.

12 Jun 24

Hanson James S.

09 Jun 23

Hanson James S.

05 Jan 23

Hanson James S.

08 Sep 20

Hanson James S.

27 Jun 18

Mossinghoff Gregory J

Mossinghoff Gregory J

16 May 17

Mossinghoff Gregory J

02 Mar 05

Mossinghoff Gregory J

01 Dec 04

Mossinghoff Gregory J

17 Oct 03

Statement Of Changes In Beneficial Ownership Of Securities.

03 Jan 03

Nicholson Garry A

Nicholson Garry A

28 Jun 21

Nicholson Garry A

21 Jun 21

Nicholson Garry A

17 Jun 20

Nicholson Garry A

12 Jun 19

Nicholson Garry A

05 Jun 18

Phillips Barclay A

Phillips Barclay A

02 Jan 19

Phillips Barclay A

06 Dec 17

Phillips Barclay A

25 Mar 14

Phillips Barclay A

09 Feb 06

Phillips Barclay A

16 Jun 05

Ra Capital Management, Llc

Amended Statement Of Beneficial Ownership Of More Than 5%.

13 Nov 24

Ra Capital Management, L.p.

25 Jul 23

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Nov 22

16 Feb 21

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 14

Rivers Tyrell

Rivers Tyrell

02 Jan 24

Rivers Tyrell

16 Mar 21

Rivers Tyrell

02 Oct 19

Rivers Tyrell

17 Oct 18

Rivers Tyrell

16 May 17

Shaffer Christy L

Shaffer Christy L

23 Jun 23

Shaffer Christy L

26 Mar 21

Shaffer Christy L

23 Mar 07

Shaffer Christy L

02 Jun 04

Shaffer Christy L

13 Jan 04

Strum Jay

Strum Jay

02 Jan 19

Strum Jay

31 Aug 18

Strum Jay

04 Jan 18

Strum Jay

24 May 17

Strum Jay

19 May 17

Sullivan Timothy Eugene

Sullivan Timothy Eugene

19 Apr 24

Sullivan Timothy Eugene

13 Feb 24

Sullivan Timothy Eugene

23 Jan 24

Sullivan Timothy Eugene

03 May 23

Sullivan Timothy Eugene

25 Jan 22

Witty Andrew

Witty Andrew

07 Jun 23

Witty Andrew

27 Feb 23

Witty Andrew

30 Jun 22

Witty Andrew

24 Mar 22

Witty Andrew

28 Jun 18

Eshelman Fredric N

Eshelman Ventures, Llc

13 Jan 21

Eshelman Ventures, Llc

01 Dec 20

Eshelman Fredric N

21 Jun 16

14 Feb 11

Eshelman Fredric N

17 Jul 07

Fmr Llc

09 Feb 22

14 Feb 14

16 Feb 10

10 Nov 03

11 Feb 97

Hatteras Venture Partners Iv Sbic, Lp

14 Feb 22

Thorp Clay

04 Dec 17

Hatteras Venture Advisors Iv Sbic, Llc

19 Jan 17

Hatteras Venture Advisors Iv Sbic, Llc

07 Jun 16

Hatteras Venture Advisors Iv Sbic, Llc

01 Jun 16

State Street Corp

14 Feb 18

Perretta Christopher

19 May 15

11 Feb 11

Correspondence With The Sec.

18 Nov 10

Statement Of Changes In Beneficial Ownership Of Securities.

22 Aug 00

Beryl Capital Management Llc

01 Apr 24

25 Sep 23

Quarterly Holdings Report

14 Feb 23

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Feb 22

13 Aug 21

Blackrock Inc.

31 Jan 19

30 Jan 19

08 Jul 16

04 Feb 11

09 Feb 07

Lumira Capital Investment Management Inc.

Acquired More Than 5% Ownership Of Any Class Of A Company's Securities.

08 Nov 23

Van Der Velden Peter

03 Nov 20

Van Der Velden Peter

10 Jan 20

Amended Statement Of Beneficial Ownership Of More Than 5%.

13 Sep 19

Van Der Velden Peter

11 Jun 19

Franklin Resources Inc

07 Feb 17

02 Feb 15

06 Nov 06

09 Feb 01

06 Jan 00

Vanguard Group Inc

11 Feb 19

11 Feb 16

10 Feb 16

12 Feb 14

12 Feb 14

Astrazeneca Plc

Report Of Foreign Private Issuer Pursuant To Rules 13a-16 And 15d-16.

21 Feb 24

Report Of Foreign Private Issuer Pursuant To Rules 13a-16 And 15d-16.

25 Oct 22

Report Of Foreign Private Issuer Pursuant To Rules 13a-16 And 15d-16.

20 Aug 21

Report Of Foreign Private Issuer Pursuant To Rules 13a-16 And 15d-16.

12 Mar 20

Report Of Foreign Private Issuer Pursuant To Rules 13a-16 And 15d-16.

28 Sep 16

Wellington Management Group Llp

12 Feb 19

12 Mar 12

14 Feb 08

12 Feb 02

13 Feb 01

Jpmorgan Chase & Co

Free Writing Prospectuses - Filing Under Securities Act Rules 163/433.

07 Sep 23

Prospectus Filed Pursuant To Rule 424(b)(2).

08 Jun 23

Prospectus Filed Pursuant To Rule 424(b)(2).

20 Jul 21

Free Writing Prospectuses - Filing Under Securities Act Rules 163/433.

01 Sep 11

Free Writing Prospectuses - Filing Under Securities Act Rules 163/433.

05 Sep 06