Aldrich Richard

Aldrich Richard

18 Jan 18

Aldrich Richard

18 May 16

Aldrich Richard

09 Apr 15

Aldrich Richard

24 Jul 13

Aldrich Richard

02 Oct 06

Basta Steven L

Basta Steven L

12 Aug 22

Basta Steven L

31 May 19

Basta Steven L

03 Apr 19

Basta Steven L

14 Sep 18

Basta Steven L

05 Nov 07

Cha Albert

Cha Albert

28 Sep 23

Cha Albert

15 Mar 18

Cha Albert

21 Jul 15

Cha Albert

27 Apr 15

Cha Albert

14 Feb 08

Clapper David M

Clapper David M

30 Apr 18

Clapper David M

29 Apr 13

Clapper David M

24 May 12

Clapper David M

01 Jun 06

Clapper David M

28 Apr 05

Crockett Thomas Andrew

Crockett Thomas Andrew

05 Feb 24

Crockett Thomas Andrew

21 Nov 23

Crockett Thomas Andrew

07 Sep 22

Crockett Thomas Andrew

15 Mar 19

Crockett Thomas Andrew

28 Nov 16

Edwards Martin

Edwards Martin

21 Aug 24

Edwards Martin

17 Jun 21

Edwards Martin

04 Jan 21

Edwards Martin

28 Jun 19

Edwards Martin

05 May 15

Feener Edward P.

Edward Feener

08 Jan 24

Feener Edward P.

21 Nov 23

Feener Edward P.

19 Aug 22

Feener Edward P.

08 Feb 21

Feener Edward P.

18 Apr 19

Gravett David M.

Gravett David M.

05 Jan 16

Gravett David M.

05 Aug 15

Gravett David M.

08 Apr 15

Katkin Keith

Katkin Keith

19 May 17

Katkin Keith

31 Mar 17

Katkin Keith

05 Dec 12

Katkin Keith

12 Sep 07

Katkin Keith

08 Dec 05

Lewis Hayley

Lewis Hayley

07 Jun 21

Lewis Hayley

01 Apr 21

Lewis Hayley

19 Jun 19

Lewis Hayley

27 Apr 18

Lewis Hayley

24 Jun 16

Maetzel Andreas

Maetzel Andreas

28 May 21

Maetzel Andreas

29 Apr 21

Maetzel Andreas

08 Feb 21

Maetzel Andreas

17 May 19

Maetzel Andreas

09 Mar 17

Maroney Marcee

Maroney Marcee

22 Nov 16

Maroney Marcee

05 Jan 16

Maroney Marcee

05 Aug 15

Maroney Marcee

08 Apr 15

Mckune John

Mckune John

05 Dec 23

Mckune John

19 Oct 23

Mckune John

05 Jan 16

Mckune John

04 Nov 15

Mckune John

12 Aug 15

Nohra Guy P

Nohra Guy P

05 Apr 22

Alta Partners Viii, L.p.

10 Dec 14

Alta Partners Viii, L.p.

19 Nov 14

Alta Partners Ii Inc

15 Oct 04

Deleage Jean

07 Apr 04

Oronsky Arnold L

Interwest Partners Ix, Lp

22 May 14

Oronsky Arnold L

31 May 12

Interwest Partners Ix, Lp

02 Aug 10

Oronsky Arnold L

15 Jun 07

Oronsky Arnold L

06 Nov 03

Pereira Brian Jg

Pereira Brian Jg

20 Dec 11

Pereira Brian Jg

27 Sep 07

Pereira Brian Jg

06 Sep 07

Pereira Brian Jg

03 May 05

Pereira Brian Jg

29 Jul 04

Ra Capital Management, Llc

Amended Statement Of Beneficial Ownership Of More Than 5%.

13 Nov 24

Ra Capital Management, L.p.

25 Jul 23

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Nov 22

16 Feb 21

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 14

Ramiya Premchandran

Ramiya Premchandran

05 Jan 16

Ramiya Premchandran

05 Aug 15

Ramiya Premchandran

05 Aug 15

Renzi David

Renzi David

14 Jun 22

Renzi David

23 Nov 16

Renzi David

05 Jan 16

Renzi David

31 Dec 15

Renzi David

05 Aug 15

Resnick Joshua

Resnick Joshua

21 Jun 24

Resnick Joshua

02 Jun 23

Resnick Joshua

29 Jun 21

Resnick Joshua

04 Feb 21

Resnick Joshua

27 Mar 17

Saul David Joseph

Saul David Joseph

02 Feb 16

Saul David Joseph

02 Feb 16

Shah Rajeev M.

Ra Capital Management, L.p.

13 Jun 23

Ra Capital Management, L.p.

21 Nov 22

Ra Capital Management, L.p.

07 May 20

Ra Capital Management, L.p.

31 Mar 20

Shah Rajeev M.

22 Jun 18

Smith Michael David

Smith Michael David

19 May 22

Smith Michael David

03 Jun 21

Smith Michael David

28 May 21

Smith Michael David

18 Dec 20

Smith Michael David

05 Jun 19

Soland Daniel B

Soland Daniel B

05 Jun 23

Soland Daniel B

28 Jun 19

Soland Daniel B

15 Jan 08

Soland Daniel B

07 Nov 06

Soland Daniel B

22 Feb 06

Stuart Nancy

Stuart Nancy

01 Feb 22

Stuart Nancy

07 Feb 19

Stuart Nancy

08 Jan 19

Annual Statement Of Changes In Beneficial Ownership Of Securities.

08 Jan 16

Stuart Nancy

03 Nov 15

Unkart Edward W

Unkart Edward W

04 Oct 24

Unkart Edward W

01 Oct 21

Unkart Edward W

29 Sep 17

Unkart Edward W

05 Aug 15

Unkart Edward W

25 Feb 09

White Thomas Michael

White Thomas Michael

08 Apr 15

Yea Christopher

Yea Christopher

19 Nov 24

Yea Christopher

18 Dec 20

Yea Christopher

23 Apr 19

Yea Christopher

29 Jan 19

Yea Christopher

29 Nov 16

Zadno Reza

Reza Zadno

13 Nov 24

Zadno Reza

23 Aug 24

Zadno Reza

21 Sep 21

Zadno Reza

14 Sep 21

Zadno Reza

23 May 16

Novo Holdings A/s

14 Feb 24

Amended Statement Of Beneficial Ownership Of More Than 5%.

24 Aug 21

Amended Statement Of Beneficial Ownership Of More Than 5%.

17 Feb 21

Amended Statement Of Beneficial Ownership Of More Than 5%.

31 Mar 17

Novo A/s

11 Feb 14

Kalvista Pharmaceuticals Ltd

Acquired More Than 5% Ownership Of Any Class Of A Company's Securities.

27 Jun 16

Svlsf Iv, Llc

Svlsf Iv, Llc

20 Mar 19

06 Aug 18

Amended Statement Of Beneficial Ownership Of More Than 5%.

07 Feb 17

Amended Statement Of Beneficial Ownership Of More Than 5%.

23 Apr 14

Svlsf Iv, Llc

02 Oct 13

Tang Capital Partners Lp

Amended Statement Of Beneficial Ownership Of More Than 5%.

05 Jun 20

Amended Statement Of Beneficial Ownership Of More Than 5%.

30 Jul 12

17 Jul 09

Definitive Information Statement By Non-management.

28 May 09

23 Mar 05

Suvretta Capital Management, Llc

13 Feb 24

Amended Statement Of Beneficial Ownership Of More Than 5%.

13 Feb 23

02 Nov 22

10 Dec 21

Quarterly Holdings Report

14 Feb 17

Eventide Asset Management, Llc

11 Dec 23

14 Feb 23

Quarterly Holdings Report

13 Feb 23

Quarterly Holdings Report

14 May 21

Amended Statement Of Beneficial Ownership Of More Than 5%.

12 Feb 21

Franklin Resources Inc

07 Feb 17

02 Feb 15

06 Nov 06

09 Feb 01

06 Jan 00

Price T Rowe Associates Inc /md/

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 22

10 Feb 16

10 Feb 98

05 Feb 98

Tcg Crossover Gp I, Llc

19 Apr 24

09 Feb 24

09 Feb 24

25 Jul 23

14 Feb 23

Frazier Life Sciences Public Fund, L.p.

29 May 24

09 Apr 24

Amended Statement Of Beneficial Ownership Of More Than 5%.

07 Oct 22

29 Apr 22

17 Dec 21

Ikarian Capital, Llc

07 Oct 24

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 22

Quarterly Holdings Report

17 May 21

30 Dec 20

Ikarian Capital, Llc

14 Sep 20

Deep Track Capital, Lp

22 Nov 24

12 Apr 24

08 Mar 24

14 Feb 24

25 Oct 21

Vivo Ventures Vi, Llc

Amended Statement Of Beneficial Ownership Of More Than 5%.

06 Aug 21

Vivo Ventures Vi, Llc

24 Apr 15

Vivo Ventures Vi, Llc

08 Apr 15

Vivo Ventures Vi, Llc

17 Sep 13

Vivo Ventures Fund Vi, L.p.

13 Aug 09

Adage Capital Management, L.p.

12 Nov 24

12 Nov 24

12 Nov 24

14 Aug 24

Adage Capital Management, L.p.

08 May 24

Flynn James E

14 Nov 24

10 Feb 20

16 Apr 15

Flynn James E

31 Dec 08

Flynn James E

24 May 06

Vanguard Group Inc

11 Feb 19

11 Feb 16

10 Feb 16

12 Feb 14

12 Feb 14

Vivo Capital Ix, Llc

14 Nov 24

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Feb 22

Vivo Opportunity, Llc

31 Jan 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

12 Feb 21

Vivo Opportunity, Llc

31 Jan 20

Merck & Co., Inc.

Results Of Operations And Financial Condition, Financial Statements And Exhibits

29 Apr 21

Holston Michael J

24 Feb 16

Thier Samuel O Md

05 Nov 09

Queisser Lori A.

01 Mar 07

Cheeley C Ron

13 Dec 06

Longwood Fund Ii, L.p.

Amended Statement Of Beneficial Ownership Of More Than 5%.

10 Feb 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

19 May 16

Amended Statement Of Beneficial Ownership Of More Than 5%.

22 Mar 16

Longwood Fund Ii, L.p.

13 Feb 15

Longwood Fund Ii, L.p.

30 Jan 15

Fmr Llc

09 Feb 22

14 Feb 14

16 Feb 10

10 Nov 03

11 Feb 97

Tang Capital Management Llc

Tang Kevin C

24 Aug 22

Quarterly Holdings Report

17 May 21

Quarterly Holdings Report

16 Feb 21

Tang Kevin C

09 May 12

Tang Kevin C

24 Sep 08

Interwest Partners Ix, Lp

Interwest Partners Ix, Lp

13 Aug 18

Interwest Partners Ix, Lp

27 Feb 14

Interwest Management Partners Ix, Llc

16 May 13

13 Feb 09

Interwest Partners Ix, Lp

21 Nov 07

Adage Capital Partners Gp, L.l.c.

07 Feb 24

07 Feb 24

Amended Statement Of Beneficial Ownership Of More Than 5%.

09 Feb 23

08 Jan 10

Adage Capital Partners Gp Llc

26 Feb 04

Acp Iv, L.p.

Acquired More Than 5% Ownership Of Any Class Of A Company's Securities.

24 Apr 15

Acmp Iv Llc

14 Apr 15

Acp Iv, L.p.

18 Jul 14

Amended Statement Of Beneficial Ownership Of More Than 5%.

18 Dec 12

Acp Iv, L.p.

10 Feb 11

Wellington Management Group Llp

12 Feb 19

12 Mar 12

14 Feb 08

12 Feb 02

13 Feb 01

Broadfin Capital, Llc

Amended Statement Of Beneficial Ownership Of More Than 5%.

23 Dec 19

Broadfin Healthcare Master Fund Ltd

20 Nov 17

Quarterly Holdings Report

14 Nov 17

04 Oct 13

19 Jul 11

Venrock Healthcare Capital Partners Iii, L.p.

14 Nov 24

14 Feb 24

14 Feb 24

30 Jun 23

Venrock Healthcare Capital Partners Ii, L.p.

25 Jul 22

Ra Capital Management, L.p.

Amended Statement Of Beneficial Ownership Of More Than 5%.

13 Nov 24

Ra Capital Management, L.p.

25 Jul 23

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Nov 22

16 Feb 21

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 14

Great Point Partners Llc

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 19

Amended Statement Of Beneficial Ownership Of More Than 5%.

17 Feb 15

21 Jul 14

Great Point Partners Llc

23 May 08

Great Point Partners Llc

04 Jun 04

Blackrock Inc.

31 Jan 19

30 Jan 19

08 Jul 16

04 Feb 11

09 Feb 07

Venrock Healthcare Capital Partners Ii, L.p.

14 Feb 24

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 23

Venrock Healthcare Capital Partners Ii, L.p.

26 Oct 22

29 Apr 22

Venrock Associates Iv L P

14 Mar 19

Vestal Point Capital, Lp

14 Nov 24

Quarterly Holdings Report

14 Nov 24

14 Nov 24

13 Feb 24

13 Feb 24

Capital World Investors

11 Feb 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Feb 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Feb 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 20

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 20