Baltera Robert Jr.

Baltera Robert Jr.

28 Aug 17

Baltera Robert Jr.

26 Aug 14

Baltera Robert Jr.

16 Jun 14

Baltera Robert Jr.

21 Dec 12

Baltera Robert Jr.

07 Sep 12

Baracchini Edgardo Jr

Baracchini Edgardo Jr

26 Jan 18

Baracchini Edgardo Jr

02 May 17

Baracchini Edgardo Jr

03 Sep 15

Baracchini Edgardo Jr

14 May 15

Baracchini Edgardo Jr

01 May 15

Carter Bruce L A

Carter Bruce L A

06 Jun 17

Carter Bruce L A

16 Jun 14

Carter Bruce L A

23 Aug 10

Carter Bruce L A

11 Jun 09

Carter Bruce L A

15 May 09

Cornelissen Bart Jan

Cornelissen Bart Jan

11 Apr 24

Cornelissen Bart Jan

11 Apr 24

Dahiyat Bassil I

Dahiyat Bassil I

07 Mar 24

Dahiyat Bassil I

13 Mar 23

Dahiyat Bassil I

06 Mar 23

Dahiyat Bassil I

10 Mar 22

Dahiyat Bassil I

02 Jul 21

Desjarlais John R

Desjarlais John R

05 Mar 24

Desjarlais John R

05 Aug 16

Desjarlais John R

03 Mar 16

Desjarlais John R

15 Jan 16

Desjarlais John R

02 Feb 15

Eckert Celia

Eckert Celia

12 Mar 24

Eckert Celia

07 Mar 24

Notice Of Proposed Sale Of Securities Under Rule 144.

09 Mar 23

Eckert Celia

06 Mar 23

Eckert Celia

10 Mar 21

Feigal Ellen

Feigal Ellen

01 Oct 24

Feigal Ellen

23 Jun 23

Feigal Ellen

25 Jun 21

Feigal Ellen

09 Nov 18

Feigal Ellen

09 Nov 18

Fleming Jonathan

Fleming Jonathan

02 Dec 13

Fleming Jonathan

05 Jan 09

Oxford Bioscience Partners Iii Lp

14 Dec 05

Oxford Bioscience Partners Ii L P

18 Aug 05

Oxford Bioscience Partners Iv Lp

21 Apr 05

Foster Paul A

Foster Paul A

14 Feb 19

Foster Paul A

17 Aug 18

Foster Paul A

16 Aug 18

Foster Paul A

22 Feb 18

Foster Paul A

26 Aug 16

Gorman Kevin Charles

Gorman Kevin Charles

15 Feb 24

Gorman Kevin Charles

19 Dec 14

Gorman Kevin Charles

03 Mar 10

Gorman Kevin Charles

15 Jan 09

Gorman Kevin Charles

27 May 03

Gustafson Kurt A

Gustafson Kurt A

09 Dec 22

Gustafson Kurt A

27 Jun 22

Gustafson Kurt A

29 Jun 20

Gustafson Kurt A

11 Jun 15

Gustafson Kurt A

06 Feb 13

Hata Yujiro S

Hata Yujiro S

19 Dec 23

Yujiro Hata

15 Dec 23

Yujiro Hata

15 Dec 23

Hata Yujiro S

26 Feb 21

Hata Yujiro S

23 Dec 20

Klencke Barbara

Klencke Barbara

14 Jun 24

Klencke Barbara

19 Sep 23

Klencke Barbara

24 Jan 23

Klencke Barbara

13 Jun 22

Klencke Barbara

02 Nov 21

Kuch John J

Kuch John J

12 Mar 24

Kuch John J

08 Mar 23

Annual Statement Of Changes In Beneficial Ownership Of Securities.

16 Feb 23

Kuch John J

03 Mar 21

Kuch John J

22 Apr 14

Montgomery Alan Bruce

Montgomery Alan Bruce

03 Mar 21

Montgomery Alan Bruce

27 Jun 19

Montgomery Alan Bruce

28 May 19

Montgomery Alan Bruce

09 Feb 18

Montgomery Alan Bruce

03 Jun 16

Ranieri Richard J

Ranieri Richard J

27 Jun 18

Ranieri Richard J

01 Aug 12

Ranieri Richard J

31 May 11

Ranieri Richard J

30 Apr 10

Ranieri Richard J

16 Jan 07

Rosa-bjorkeson Dagmar

Rosa-bjorkeson Dagmar

17 Jun 24

Rosa-bjorkeson Dagmar

27 May 22

Rosa-bjorkeson Dagmar

20 Dec 19

Rosa-bjorkeson Dagmar

05 Apr 19

Rosa-bjorkeson Dagmar

05 Jun 18

Rowland Lloyd A

Rowland Lloyd A

20 Mar 15

Rowland Lloyd A

02 Sep 14

Rowland Lloyd A

18 May 06

Rowland Lloyd A

13 Feb 06

Rowland Lloyd A

08 Sep 03

Saran Atul

Saran Atul

26 Feb 21

Saran Atul

27 Feb 20

Saran Atul

29 Apr 16

Saran Atul

09 Jun 14

Saran Atul

06 Dec 13

Valente Nancy

Valente Nancy

10 Mar 23

Valente Nancy

28 Oct 22

Valente Nancy

09 Sep 22

Valente Nancy

09 Sep 22

Valente Nancy

09 Nov 21

Werner Harold R

Healthcare Ventures Vii Lp

08 Jul 14

Werner Harold R

02 Dec 13

Healthcare Ventures Vii Lp

07 Aug 07

Healthcare Ventures Vi Lp

06 Jul 06

Healthcare Ventures V L P

05 Apr 04

Yang Allen

Yang Allen

20 Dec 21

Yang Allen

10 Mar 21

Yang Allen

03 Mar 21

Yang Allen

18 Dec 19

Yang Allen

18 Dec 19

Blackrock Funding, Inc. /de

08 Nov 24

23 Oct 24

23 Oct 24

21 Oct 24

18 Oct 24

Ra Capital Management, L.p.

Amended Statement Of Beneficial Ownership Of More Than 5%.

13 Nov 24

Ra Capital Management, L.p.

25 Jul 23

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Nov 22

16 Feb 21

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 14

Redmile Group, Llc

Quarterly Holdings Report

14 Nov 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 22

16 Feb 21

Redmile Group, Llc

16 Sep 16

Quarterly Holdings Report

14 Aug 12

Adage Capital Partners Gp, L.l.c.

07 Feb 24

07 Feb 24

Amended Statement Of Beneficial Ownership Of More Than 5%.

09 Feb 23

08 Jan 10

Adage Capital Partners Gp Llc

26 Feb 04

Blackrock Inc.

31 Jan 19

30 Jan 19

08 Jul 16

04 Feb 11

09 Feb 07

Perceptive Advisors Llc

14 Mar 23

Perceptive Advisors Llc

29 Sep 21

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 19

09 Nov 17

Quarterly Holdings Report

16 Nov 09

Vanguard Group Inc

11 Feb 19

11 Feb 16

10 Feb 16

12 Feb 14

12 Feb 14

Fmr Llc

09 Feb 22

14 Feb 14

16 Feb 10

10 Nov 03

11 Feb 97

Flynn James E

14 Nov 24

10 Feb 20

16 Apr 15

Flynn James E

31 Dec 08

Flynn James E

24 May 06

Stafford John S Jr

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Mar 11

Stafford John S Jr

13 Jan 09

Stafford John S Jr

17 Dec 08

Stafford John S Jr

29 Sep 08

Stafford John S Jr

14 Jan 08

T. Rowe Price Investment Management, Inc.

14 Nov 24

14 Nov 24

14 Feb 24

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 23

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 23

Price T Rowe Associates Inc /md/

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 22

10 Feb 16

10 Feb 98

05 Feb 98

Stafford John S Iii

Amended Statement Of Beneficial Ownership Of More Than 5%.

20 Sep 22

Stafford John S Iii

02 Jul 21

Ronin Capital, Llc

15 Nov 19

Ronin Capital, Llc

12 Nov 19

Ronin Capital, Llc

07 May 14

Ecor1 Capital, Llc

14 Feb 24

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 23

Acquired More Than 5% Ownership Of Any Class Of A Company's Securities.

10 Mar 21

22 Jan 21

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Mar 19

Primecap Management Co/ca/

Amended Statement Of Beneficial Ownership Of More Than 5%.

09 Oct 20

Amended Statement Of Beneficial Ownership Of More Than 5%.

12 Feb 20

Amended Statement Of Beneficial Ownership Of More Than 5%.

27 Feb 18

08 Nov 05

13 Nov 03

State Street Corp

14 Feb 18

Perretta Christopher

19 May 15

11 Feb 11

Correspondence With The Sec.

18 Nov 10

Statement Of Changes In Beneficial Ownership Of Securities.

22 Aug 00