Barnes Susan K

Barnes Susan K

15 Mar 16

Barnes Susan K

18 Mar 14

Barnes Susan K

18 Mar 13

Barnes Susan K

12 May 06

Barnes Susan K

05 Aug 05

Botstein David

Botstein David

27 May 22

Botstein David

17 Feb 21

Botstein David

06 Aug 20

Botstein David

23 May 18

Botstein David

19 May 16

Byers Brook H

Byers Brook H

21 May 14

Byers Brook H

04 Nov 13

Byers Brook H

29 Oct 13

Byers Brook H

15 Jun 12

Byers Brook H

27 Jun 11

Corcoran Kevin P

Corcoran Kevin P

28 Nov 17

Corcoran Kevin P

15 Jun 17

Corcoran Kevin P

16 Feb 17

Annual Statement Of Changes In Beneficial Ownership Of Securities.

09 Feb 16

Corcoran Kevin P

27 Oct 04

Dow Brian B

Dow Brian B

18 May 17

Dow Brian B

17 Feb 12

Dow Brian B

26 Oct 10

Dow Brian B

06 Feb 09

Dow Brian B

09 Jan 09

Eidel Jeff

Jeffrey Eidel

19 Aug 24

Jeffrey Eidel

16 Feb 24

Eidel Jeff

18 Aug 23

Jeffrey Eidel

17 Aug 23

Eidel Jeff

18 Aug 22

Ericson William W.

Ericson William W.

26 May 23

Ericson William W.

15 Jun 17

Mdv Ix Lp

14 Oct 16

Ericson William W.

27 Sep 13

Ericson William W.

23 Sep 13

Farmer Michele

Farmer Michele

22 May 24

Farmer Michele

06 Mar 23

Farmer Michele

04 Mar 22

Farmer Michele

19 May 21

Farmer Michele

19 May 21

Fromen Peter

Fromen Peter

04 Mar 22

Fromen Peter

13 Jan 22

Fromen Peter

12 Jan 21

Fromen Peter

12 Jan 21

Glynn Michael

Glynn Michael

10 Jun 13

Glynn Michael

09 Nov 12

Glynn Michael

17 Feb 12

Glynn Michael

04 Oct 11

Gong Benjamin B

Gong Benjamin B

13 Aug 20

Gong Benjamin B

17 Feb 06

Gong Benjamin B

09 Feb 06

Gong Benjamin B

15 Dec 05

Gong Benjamin B

18 Nov 05

Henry Christian O

Henry Christian O

14 Mar 22

Henry Christian O

14 Nov 16

Henry Christian O

01 Feb 16

Henry Christian O

12 Aug 11

Henry Christian O

14 Oct 09

Hunkapiller Michael

Hunkapiller Michael

18 Mar 13

Hunkapiller Michael

16 Nov 12

Hunkapiller Michael

08 Aug 12

Hunkapiller Michael

09 Jan 12

Hunkapiller Michael

27 Jun 11

Kim Susan G.

Kim Susan G.

02 Oct 24

Kim Susan G.

22 Feb 23

Kim Susan G.

03 Oct 22

Kim Susan G.

18 Feb 21

Kim Susan G.

30 Sep 20

Livingston Randall S

Livingston Randall S

06 Aug 20

Livingston Randall S

23 May 18

Livingston Randall S

19 May 16

Livingston Randall S

29 Apr 11

Livingston Randall S

20 Sep 06

Martin Hugh C

Martin Hugh C

31 May 11

Martin Hugh C

10 Jun 09

Martin Hugh C

12 Feb 09

Martin Hugh C

13 Jun 07

Martin Hugh C

07 Jun 07

Meline David W

Meline David W

03 Aug 16

Meline David W

05 Aug 14

Meline David W

07 Feb 13

Meline David W

06 Sep 11

Meline David W

02 Sep 10

Milligan John F

Milligan John F

08 Jun 16

Milligan John F

03 Feb 15

Milligan John F

27 Jan 14

Milligan John F

27 Jan 06

Milligan John F

02 May 05

Mohr Marshall

Mohr Marshall

19 May 16

Mohr Marshall

11 Feb 11

Mohr Marshall

01 Feb 11

Mohr Marshall

02 Dec 09

Mohr Marshall

21 Mar 06

Ordonez Kathy

Ordonez Kathy

17 Feb 22

Ordonez Kathy

18 Feb 21

Ordonez Kathy

03 Dec 10

Ordonez Kathy

20 Aug 07

Ordonez Kathy

05 Feb 07

Phillips James Michael

Phillips James Michael

16 Feb 17

Phillips James Michael

31 Oct 16

Phillips James Michael

11 Aug 15

Phillips James Michael

02 Mar 15

Phillips James Michael

18 Feb 15

Schaefer Eric

Schaefer Eric

24 Feb 21

Schaefer Eric

18 Feb 21

Schaefer Eric

05 Jun 20

Seipert Christopher J.

Seipert Christopher J.

02 Apr 20

Shapiro Lucy

Shapiro Lucy

12 Dec 14

Shapiro Lucy

30 May 14

Shapiro Lucy

19 Apr 13

Shapiro Lucy

24 Sep 12

Shapiro Lucy

05 Jan 12

Siegel Susan E

Siegel Susan E

27 May 22

Siegel Susan E

26 Oct 10

Siegel Susan E

04 Jan 06

Siegel Susan E

02 Dec 05

Siegel Susan E

02 Feb 05

Singer David B

Singer David B

18 Feb 22

Singer David B

30 Jan 20

Annual Statement Of Changes In Beneficial Ownership Of Securities.

14 Feb 06

Singer David B

29 Dec 05

Singer David B

26 May 04

Turner Stephen W

Turner Stephen W

11 Jul 11

Turner Stephen W

06 Jul 11

Turner Stephen W

17 Jun 11

Turner Stephen W

26 Oct 10

Valantine Hannah

Valantine Hannah

20 Feb 24

Valantine Hannah

13 Feb 24

Valantine Hannah

17 Nov 23

Valantine Hannah

21 Jun 23

Valantine Hannah

24 Jun 22

Van Oene Mark

Van Oene Mark

05 May 20

Van Oene Mark

06 Feb 20

Van Oene Mark

03 Oct 19

Van Oene Mark

13 Dec 17

Van Oene Mark

07 Nov 17

Zaccarin Denis

Zaccarin Denis

02 Apr 20

Millennium Management Llc

Amended Statement Of Beneficial Ownership Of More Than 5%.

27 Jan 23

20 Jan 23

Quarterly Holdings Report

14 Nov 18

Quarterly Holdings Report

14 Nov 16

Riverview Group Llc

07 Jan 05

Gen Probe Inc

Other Events

29 Aug 11

Kacian Daniel L

14 Feb 11

Amended Statement Of Beneficial Ownership Of More Than 5%.

09 Nov 10

Departure Of Directors Or Principal Officers; Election Of Directors; Appointment Of Principal Officers, Financial Statements And Exhibits

21 Sep 07

Tartre Don

26 Jan 04

Madrone Capital Partners, Llc

Madrone Capital Partners, Llc

04 Dec 23

04 Dec 23

Madrone Capital Partners, Llc

29 Nov 23

01 Jun 22

Madrone Partners, L.p.

25 Sep 19

Nikko Asset Management Americas, Inc.

Amended Statement Of Beneficial Ownership Of More Than 5%.

10 Feb 23

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Feb 21

Amended Statement Of Beneficial Ownership Of More Than 5%.

12 Feb 20

Quarterly Holdings Report

28 Oct 16

Quarterly Holdings Report

08 Feb 10

Kleiner Perkins Caufield & Byers Xi-a Lp

16 Feb 16

Kleiner Perkins Caufield & Byers Xi-a Lp

12 May 15

Kleiner Perkins Caufield & Byers Xi-a Lp

12 Mar 15

14 Feb 11

Form D Notice Of An Exempt Offering Of Securities Under Regulation D.

02 Feb 09

Raging Capital Management, Llc

Amended Statement Of Beneficial Ownership Of More Than 5%.

03 Jan 17

Martin William C

02 Sep 11

18 Dec 09

Martin William C

10 Dec 09

26 Sep 08

Samana Capital, L.p.

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 11

Amended Statement Of Beneficial Ownership Of More Than 5%.

31 Jul 09

Amended Statement Of Beneficial Ownership Of More Than 5%.

13 Feb 06

28 May 04

Amended Statement Of Beneficial Ownership Of More Than 5%.

17 Feb 04

Ics Opportunities, Ltd.

18 Oct 23

17 Feb 23

06 Nov 19

23 Dec 11

11 Jul 11

Ark Investment Management Llc

29 Jan 24

10 Sep 21

Amended Statement Of Beneficial Ownership Of More Than 5%.

16 Feb 21

Quarterly Holdings Report

13 May 19

14 Feb 19

Invesco Ltd.

Amended Statement Of Beneficial Ownership Of More Than 5%.

10 Aug 22

Taylor Philip

03 Mar 15

Prospectus Filed Pursuant To Rule 424(b)(7).

02 Jun 10

11 Feb 10

13 Feb 09

Mdv Vii Lp

Mdv Ix Lp

16 Sep 16

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Feb 16

Mdv Ix Lp

14 Apr 15

17 Feb 15

Mdv Vii Lp

19 Apr 12

Consonance Capital Management Lp

Amended Statement Of Beneficial Ownership Of More Than 5%.

16 Feb 21

14 Feb 20

14 Feb 19

Quarterly Holdings Report

14 Aug 18

Quarterly Holdings Report

14 Nov 13

Capital International Investors

13 Nov 24

13 Feb 23

11 Feb 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

16 Feb 21

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 18

Ubs Group Ag

Quarterly Holdings Report

11 Aug 23

Report Of Foreign Private Issuer Pursuant To Rules 13a-16 And 15d-16.

01 Feb 22

Ubs Group Ag

11 Jan 17

21 Jan 15

Amended Statement Of Beneficial Ownership Of More Than 5%.

02 Dec 14

Capital World Investors

11 Feb 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Feb 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Feb 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 20

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 20

Jackson Square Partners, Llc

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Feb 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Feb 22

Amended Statement Of Beneficial Ownership Of More Than 5%.

09 Feb 21

16 Feb 16

Quarterly Holdings Report

10 Feb 15

Blackrock Inc.

31 Jan 19

30 Jan 19

08 Jul 16

04 Feb 11

09 Feb 07

Softbank Group Corp.

Softbank Group Capital Ltd

05 Oct 18

Amended Statement Of Beneficial Ownership Of More Than 5%.

19 Aug 15

Amended Statement Of Beneficial Ownership Of More Than 5%.

29 Aug 13

Filed In Connection With Business Combination Subject To Rule 425.

01 May 13

Acquired More Than 5% Ownership Of Any Class Of A Company's Securities.

01 Mar 01

Flynn James E

14 Nov 24

10 Feb 20

16 Apr 15

Flynn James E

31 Dec 08

Flynn James E

24 May 06

Magnetar Financial Llc

Acquired More Than 5% Ownership Of Any Class Of A Company's Securities.

12 Nov 24

Amended Statement Of Beneficial Ownership Of More Than 5%.

20 Jun 24

Acquired More Than 5% Ownership Of Any Class Of A Company's Securities.

22 Jan 24

14 Jan 22

14 Nov 12

Sumitomo Mitsui Trust Holdings, Inc.

05 Feb 21

05 Feb 21

12 Feb 20

Report Of Foreign Private Issuer Pursuant To Rules 13a-16 And 15d-16.

13 May 11

Report Of Foreign Private Issuer Pursuant To Rules 13a-16 And 15d-16.

26 Nov 10

Maverick Capital Ltd

Quarterly Holdings Report

14 Nov 24

12 Feb 18

Quarterly Holdings Report

14 Aug 08

14 Feb 08

14 Feb 07

Bridger Management, Llc

Quarterly Holdings Report

14 Aug 19

Quarterly Holdings Report

15 May 15

Bridger Management, Llc

07 Apr 15

20 Oct 14

Quarterly Holdings Report

14 Nov 11

Feinberg Larry N

Amended Statement Of Beneficial Ownership Of More Than 5%.

03 Feb 16

Feinberg Larry N

14 May 14

Amended Statement Of Beneficial Ownership Of More Than 5%.

02 Feb 10

Acquired More Than 5% Ownership Of Any Class Of A Company's Securities.

30 Mar 99

Initial Statement Of Beneficial Ownership.

17 Dec 97

Edmond De Rothschild Asset Management (france)

09 Aug 23

11 May 23

14 Feb 20

Quarterly Holdings Report

14 Nov 16

Quarterly Holdings Report

16 Feb 16

Vanguard Group Inc

11 Feb 19

11 Feb 16

10 Feb 16

12 Feb 14

12 Feb 14