Arnold Lyle J

Arnold Lyle J

02 Jun 17

Arnold Lyle J

21 Oct 16

Arnold Lyle J

07 Jul 16

Arnold Lyle J

01 Mar 16

Arnold Lyle J

02 Sep 15

Bowen R William

Bowen R William

02 Dec 11

Bowen R William

12 Mar 10

Bowen R William

19 Aug 08

Bowen R William

02 Jun 04

Bowen R William

20 Feb 04

Brown John W

Amended Statement Of Beneficial Ownership Of More Than 5%.

10 Feb 20

Brown John W

11 Feb 09

Brown John W

09 Feb 06

Brown John W

01 Nov 05

Brown John W

04 Jan 05

Conway Niall M

Conway Niall M

01 Jun 07

Conway Niall M

13 Mar 07

Conway Niall M

06 Nov 06

Conway Niall M

15 Sep 04

Conway Niall M

20 May 03

Dewalt Diana

Dewalt Diana

14 Feb 12

Dewalt Diana

30 Nov 11

Dewalt Diana

22 Sep 08

Dewalt Diana

19 Dec 07

Dewalt Diana

14 Sep 07

Dittamore Raymond V

Dittamore Raymond V

02 May 11

Dittamore Raymond V

03 May 10

Dittamore Raymond V

03 Oct 08

Dittamore Raymond V

05 Jul 05

Dittamore Raymond V

04 Oct 04

Edelshain Martin B

Edelshain Martin B

06 Nov 06

Edelshain Martin B

16 Aug 06

Edelshain Martin B

18 Oct 05

Edishain Martin B

15 Dec 03

Edishain Martin B

26 Nov 03

Freiberg Glen Paul

Freiberg Glen Paul

15 Mar 06

Freiberg Glen Paul

18 Oct 05

Freiberg Glen Paul

03 Jun 04

Freiberg Glen Paul

20 Feb 04

Freiberg Glen Paul

06 Nov 03

Gargan Paul E

Gargan Paul E

27 Jan 12

Gargan Paul E

08 Dec 11

Gargan Paul E

12 Feb 10

Gargan Paul E

19 Aug 09

Gargan Paul E

19 Aug 03

Godsey James H

Godsey James H

01 Nov 06

Godsey James H

01 Nov 06

Godsey James H

15 Sep 04

Godsey James H

20 Feb 04

Godsey James H

20 Feb 04

Hansen Brian B

Hansen Brian B

28 Aug 19

Hansen Brian B

12 Jul 19

Hansen Brian B

15 Jun 18

Hansen Brian B

24 Feb 12

Hansen Brian B

16 Feb 12

Hull Carl

Hull Carl

20 Feb 24

Hull Carl

01 Jun 22

Hull Carl

05 May 21

Hull Carl

30 Nov 20

Hull Carl

18 Aug 10

Jemison Mae

Jemison Mae

20 Oct 06

Jemison Mae

05 Oct 06

Jemison Mae

07 Jul 06

Jemison Mae

22 Sep 05

Jemison Mae

15 Oct 03

Jorgine Ellerbrock

Jorgine Ellerbrock

20 Apr 12

Jorgine Ellerbrock

17 Aug 11

Jorgine Ellerbrock

18 Aug 10

Jorgine Ellerbrock

19 Aug 08

Jorgine Ellerbrock

04 Dec 07

Kacian Daniel L

Kacian Daniel L

17 Aug 11

Kacian Daniel L

21 Oct 09

Kacian Daniel L

05 Nov 08

Kacian Daniel L

18 Oct 05

Kacian Daniel L

02 Jun 05

Kessler Armin M

Kessler Armin M

18 Apr 18

Kessler Armin M

31 May 13

Kessler Armin M

02 Jun 08

Kessler Armin M

17 Dec 07

Kessler Armin M

05 Jan 05

Kondor Stephen J

Kondor Stephen J

05 Sep 08

Kondor Stephen J

02 Sep 08

Kondor Stephen J

06 Nov 06

Kondor Stephen J

02 Aug 05

Kondor Stephen J

02 Aug 05

Kurokawa Kiyoshi

Kurokawa Kiyoshi

20 Feb 04

Kurokawa Kiyoshi

17 Feb 04

Kurokawa Kiyoshi

02 Oct 03

Kurokawa Kiyoshi

14 Aug 03

Lai Eric Hon Cheong

Lai Eric Hon Cheong

01 Sep 11

Lai Eric Hon Cheong

14 Feb 11

Lai Eric Hon Cheong

18 Aug 10

Lai Eric Hon Cheong

12 Feb 10

Lai Eric Hon Cheong

12 Feb 09

Lashley Gurney I

Lashley Gurney I

10 Mar 04

Lashley Gurney I

20 Feb 04

Lashley Gurney I

05 Nov 03

Lashley Gurney I

24 Sep 03

Lashley Gurney I

19 Aug 03

Laubach Gerald D

Laubach Gerald D

03 Apr 06

Laubach Gerald D

05 Jul 05

Laubach Gerald D

01 Apr 05

Laubach Gerald D

23 Jun 04

Laubach Gerald D

12 Apr 04

Longiaru Mathew

Longiaru Mathew

12 Sep 03

Longiaru Mathew

19 Aug 03

Martin John C

Martin John C

05 Jan 17

Martin John C

03 Nov 16

Martin John C

26 Aug 15

Martin John C

06 Jul 15

Martin John C

16 May 08

Mcnamee Brian A

Mcnamee Brian A

05 Apr 11

Mcnamee Brian A

23 Mar 10

Mcnamee Brian A

03 Apr 07

Mcnamee Brian A

12 Jan 05

Mcnamee Brian A

26 Aug 04

Merrill Lynda A

Merrill Lynda A

19 Aug 03

Merrill Lynda A

18 Aug 03

Merrill Lynda A

14 Aug 03

Merrill Lynda A

18 Jun 03

Mimms Larry

Mimms Larry

19 Jan 06

Mimms Larry

18 Oct 05

Mimms Larry

18 Oct 05

Mimms Larry

19 Sep 05

Mimms Larry

19 May 05

Nordhoff Henry L

Nordhoff Henry L

22 May 12

Nordhoff Henry L

21 May 09

Nordhoff Henry L

19 Sep 08

Nordhoff Henry L

07 Nov 05

Nordhoff Henry L

22 Sep 03

Powelson Mark A

Powelson Mark A

20 Feb 04

Powelson Mark A

18 Dec 03

Powelson Mark A

17 Dec 03

Prince Stephen M

Prince Stephen M

19 Aug 03

Rosenman Herm

Rosenman Herm

01 Aug 23

Rosenman Herm

03 Feb 20

Rosenman Herm

08 Jun 17

Rosenman Herm

07 Dec 16

Rosenman Herm

18 Oct 05

Schneider Phillip M

Schneider Phillip M

10 Nov 22

Schneider Phillip M

10 May 18

Schneider Phillip M

15 Jun 16

Schneider Phillip M

22 Apr 15

Schneider Phillip M

17 May 10

Shapiro Lucy

Shapiro Lucy

12 Dec 14

Shapiro Lucy

30 May 14

Shapiro Lucy

19 Apr 13

Shapiro Lucy

24 Sep 12

Shapiro Lucy

05 Jan 12

Shearer Peter R

Shearer Peter R

20 Feb 04

Shearer Peter R

20 Feb 04

Shearer Peter R

22 Sep 03

Shearer Peter R

22 Sep 03

Shearer Peter R

19 Aug 03

Sofaer Abraham D

Sofaer Abraham D

06 Jul 10

Sofaer Abraham D

05 Apr 10

Sofaer Abraham D

03 Apr 09

Sofaer Abraham D

05 Jul 05

Sofaer Abraham D

02 Oct 03

Sullivan Patrick J

Sullivan Patrick J

04 May 18

Sullivan Patrick J

08 Jun 15

Sullivan Patrick J

03 Oct 14

Sullivan Patrick J

06 Jul 11

Sullivan Patrick J

16 May 05

Tardif Eric

Tardif Eric

19 Nov 20

Tardif Eric

02 Aug 12

Tardif Eric

14 Feb 12

Tardif Eric

14 Feb 11

Tardif Eric

18 Aug 10

Tartre Don

Tartre Don

12 Nov 09

Tartre Don

05 Nov 08

Tartre Don

27 Aug 08

Tartre Don

03 Feb 04

Tartre Don

26 Jan 04

Vedova Robin L

Vedova Robin L

11 Aug 04

Vedova Robin L

01 Jun 04

Vedova Robin L

20 Feb 04

Vedova Robin L

17 Sep 03

Vedova Robin L

19 Aug 03

Yang Christina C

Yang Christina C

14 Feb 12

Yang Christina C

18 Aug 10

Yang Christina C

12 Feb 10

Yang Christina C

19 Aug 09

Yang Christina C

02 Sep 08

Isaly Samuel D

Orbimed Advisors Llc

21 Nov 17

Orbimed Advisors Llc

02 Oct 17

Orbimed Advisors Llc

22 Aug 17

Orbimed Advisors Llc

28 Mar 17

Orbimed Advisors Llc

03 May 11

Janus Henderson Investors Us Llc

15 May 23

13 Feb 18

14 Feb 08

17 Feb 04

13 Feb 98

Gic Private Ltd

Gic Private Ltd

17 Apr 20

Amended Statement Of Beneficial Ownership Of More Than 5%.

17 May 17

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Jul 14

Amended Statement Of Beneficial Ownership Of More Than 5%.

06 Feb 13

29 Jan 99

Blackrock Inc.

31 Jan 19

30 Jan 19

08 Jul 16

04 Feb 11

09 Feb 07

Massachusetts Financial Services Co /ma/

13 Feb 19

22 Feb 12

13 Feb 03

10 Feb 00

13 Feb 95

Sac Capital Advisors Llc

01 Jul 08

29 Apr 08

28 Mar 07

Quarterly Holdings Report

14 Nov 06

16 Feb 06

Manning & Napier Advisors Llc

16 Jan 15

03 Feb 14

07 Jul 11

Quarterly Holdings Report

10 May 01

09 Feb 98

Capital Group International, Inc.

12 Feb 07

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 05

Amended Statement Of Beneficial Ownership Of More Than 5%.

11 Feb 05

12 Dec 00

09 Aug 99

Orbimed Advisors Llc

Orbimed Advisors Llc

13 May 22

Orbimed Advisors Llc

17 Dec 21

10 Feb 09

27 Feb 07

Orbimed Advisors Llc

16 Aug 05

Bamco Inc /ny/

10 Dec 08

Amended Statement Of Beneficial Ownership Of More Than 5%.

15 May 03

Quarterly Holdings Report

14 Aug 00

15 Feb 00

17 Feb 98

Fmr Llc

09 Feb 22

14 Feb 14

16 Feb 10

10 Nov 03

11 Feb 97

Chilton Investment Co Inc

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 05

Quarterly Holdings Report

14 Feb 05

21 Oct 02

Amended Statement Of Beneficial Ownership Of More Than 5%.

14 Feb 02

Quarterly Holdings Report

17 May 99

Wellington Management Group Llp

12 Feb 19

12 Mar 12

14 Feb 08

12 Feb 02

13 Feb 01

Blackrock Institutional Trust Company, N.a.

23 Jan 07

23 Jan 07

26 Jan 06

17 Feb 04

13 Feb 98

Orbimed Capital Llc

16 May 16

14 Nov 11

14 Aug 09

Orbimed Advisors Llc

17 May 04

Amended Statement Of Beneficial Ownership Of More Than 5%.

30 Mar 04

Morgan Stanley

Prospectus Filed Pursuant To Rule 424(b)(2).

29 Oct 24

Prospectus Filed Pursuant To Rule 424(b)(2).

07 May 24

Prospectus Filed Pursuant To Rule 424(b)(2).

26 Dec 23

Prospectus Filed Pursuant To Rule 424(b)(2).

30 Aug 22

Free Writing Prospectuses - Filing Under Securities Act Rules 163/433.

30 Aug 21